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ea0029p789 | Endocrine tumours and neoplasia | ICEECE2012

The pathogenesis of non functioning pituitary adenoma with positive staining for glycoproteins is associated with MEG3/DLK1 underexpression/GSTP1 overexpression and modulated by microRNAs (miRNAs)

Paixao B. , Lima D. , Peitl P. , Dinarte A. , Saggioro F. , Moreira A. , Silva W. , Machado H. , Castro M.

Context: Pathogenesis underlying non functioning pituitary adenoma (NFPA) formation and progression has not been well established. MEG3 is strongly expressed in the normal pituitary (NP) but not in NFPA derived from gonadotroph cells. High GSTP1 gene expression also seems to contribute to gonadotroph adenoma development. Recent reports indicate a role of miRNAs in the pituitary adenoma pathogenesis.Objective: To evaluate the expression of MEG3, DLK1, GST...

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Endocrine Abstracts

The pathogenesis of non functioning pituitary adenoma with positive staining for glycoproteins is associated with MEG3/DLK1 underexpression/GSTP1 overexpression and modulated by microRNAs (miRNAs)

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